Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM50564603
Substrate
n/a
Meas. Tech.
ChEMBL_2088444 (CHEMBL4769707)
IC50
87±n/a nM
Citation
 Xu, G; Zhang, Y; Wang, H; Guo, Z; Wang, X; Li, X; Chang, S; Sun, T; Yu, Z; Xu, T; Zhao, L; Wang, Y; Yu, W Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-? type 1 receptor inhibitors. Eur J Med Chem 198:0 (2020) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
2.7.11.30 | ALK5 | AU017197 | ESK2 | TGF-beta receptor type I | TGF-beta receptor type-1 | TGFR-1 | TGFR1_MOUSE | TbetaR-I | Tgfbr1 | Transforming growth factor-beta receptor type I
Type:
n/a
Mol. Mass.:
56186.39
Organism:
Mus musculus
Description:
n/a
Residue:
503
Sequence:
MEAAAAAPRRPQLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTTTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50564603
Synonyms:
CHEMBL4777294 | US11691981, Compound 77
Type:
Small organic molecule
Emp. Form.:
C25H29F2N5O2
Mol. Mass.:
469.5269
SMILES:
CC(C)(O)c1cc(Nc2cc(Oc3cn(nc3C3CCC(F)(F)CC3)C3CC3)ccn2)ccn1
Structure:
Search PDB for entries with ligand similarity: