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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50564768
Substrate
n/a
Meas. Tech.
ChEMBL_2089125 (CHEMBL4770388)
Kd
337±n/a nM
Citation
 Cao, DS; Jiang, SL; Guan, YD; Chen, XS; Zhang, LX; Zhang, Y; Chen, AF; Yang, JM; Cheng, Y A multi-scale systems pharmacology approach uncovers the anti-cancer molecular mechanism of Ixabepilone. Eur J Med Chem 199:0 (2020) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50564768
Synonyms:
Azaepothilone b | BMS 247550-01 | BMS-247550 | BMS-247550-01 | CHEBI:63605 | Ixabepilone | Ixempra | Ixempra kit | NSC-747973
Type:
Small organic molecule
Emp. Form.:
C27H42N2O5S
Mol. Mass.:
506.698
SMILES:
[H][C@]12C[C@H](NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@@]1(C)O2)C(\C)=C\c1csc(C)n1 |r|
Structure:
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