Reaction Details Report a problem with these data
Target
mRNA cap guanine-N7 methyltransferase
Ligand
BDBM50565050
Substrate
n/a
Meas. Tech.
ChEMBL_2089929 (CHEMBL4771192)
IC50
247500±n/a nM
Citation
 Ahmed-Belkacem, R; Sutto-Ortiz, P; Guiraud, M; Canard, B; Vasseur, JJ; Decroly, E; Debart, F Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase. Eur J Med Chem 201:0 (2020) [PubMed]  Article 
Target
Name:
mRNA cap guanine-N7 methyltransferase
Synonyms:
2.1.1.56 | KIAA0398 | MCES_HUMAN | RG7MT1 | RNMT | hCMT1 | hMet | hcm1p | mRNA (guanine-N(7)-)-methyltransferase | mRNA cap guanine-N7 methyltransferase | mRNA cap methyltransferase
Type:
PROTEIN
Mol. Mass.:
54843.48
Organism:
Homo sapiens
Description:
ChEMBL_117907
Residue:
476
Sequence:
MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ
  
Inhibitor
Name:
BDBM50565050
Synonyms:
CHEMBL4793508
Type:
Small organic molecule
Emp. Form.:
C28H31ClN12O11S
Mol. Mass.:
779.138
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CN(CCO[C@@H]2[C@H](O)[C@@H](CO)O[C@H]2n2cnc3c(N)ncnc23)S(=O)(=O)c2ccc(Cl)c(c2)[N+]([O-])=O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: