Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50129623
Substrate
n/a
Meas. Tech.
ChEMBL_3572 (CHEMBL620705)
Ki
1720±n/a nM
Citation
 Berque-Bestel, I; Soulier, JL; Giner, M; Rivail, L; Langlois, M; Sicsic, S Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors. J Med Chem 46:2606-20 (2003) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:
Enzyme
Mol. Mass.:
43767.54
Organism:
Homo sapiens (Human)
Description:
Q13639
Residue:
388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
  
Inhibitor
Name:
BDBM50129623
Synonyms:
4-Amino-5-chloro-2-methoxy-benzoic acid 2-{4-[2-(5-dimethylamino-naphthalene-1-sulfonylamino)-acetyl]-piperazin-1-yl}-ethyl ester | CHEMBL312940
Type:
Small organic molecule
Emp. Form.:
C28H34ClN5O6S
Mol. Mass.:
604.117
SMILES:
COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(CC1)C(=O)CNS(=O)(=O)c1cccc2c(cccc12)N(C)C
Structure:
Search PDB for entries with ligand similarity: