Reaction Details Report a problem with these data
Target
Neuropeptide FF receptor 2
Ligand
BDBM50565179
Substrate
n/a
Meas. Tech.
ChEMBL_2090966 (CHEMBL4772229)
EC50
2400±n/a nM
Citation
 Nguyen, T; Marusich, J; Li, JX; Zhang, Y Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. J Med Chem 63:12387-12402 (2020) [PubMed]  Article 
Target
Name:
Neuropeptide FF receptor 2
Synonyms:
G-protein coupled receptor 74 | G-protein coupled receptor HLWAR77 | GPR74 | NPFF2 | NPFF2_HUMAN | NPFFR2 | NPGPR | Neuropeptide FF receptor 2 | Neuropeptide G-protein coupled receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60293.78
Organism:
Homo sapiens (Human)
Description:
NPFF2 0 HUMAN::Q9Y5X5
Residue:
522
Sequence:
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
  
Inhibitor
Name:
BDBM50565179
Synonyms:
CHEMBL4782986
Type:
Small organic molecule
Emp. Form.:
C30H40N8O4
Mol. Mass.:
576.6898
SMILES:
NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O |r|
Structure:
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