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Target
NF-kappa-B essential modulator
Ligand
BDBM50130248
Substrate
n/a
Meas. Tech.
ChEBML_84013
EC50
5000±n/a nM
Citation
 Castro, AC; Dang, LC; Soucy, F; Grenier, L; Mazdiyasni, H; Hottelet, M; Parent, L; Pien, C; Palombella, V; Adams, J Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett 13:2419-22 (2003) [PubMed]  Article 
Target
Name:
NF-kappa-B essential modulator
Synonyms:
FIP3 | IKBKG | Inhibitor of NF-kappa-B kinase (IKK) | NEMO | NEMO_HUMAN | NF-kappa-B essential modulator
Type:
PROTEIN
Mol. Mass.:
48190.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_84013
Residue:
419
Sequence:
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
  
Inhibitor
Name:
BDBM50130248
Synonyms:
CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-nicotinamide | PS-1145
Type:
Small organic molecule
Emp. Form.:
C17H11ClN4O
Mol. Mass.:
322.748
SMILES:
Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1
Structure:
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