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Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Ligand
BDBM50565951
Substrate
n/a
Meas. Tech.
ChEMBL_2094263 (CHEMBL4775526)
IC50
13±n/a nM
Citation
 Yang, Y; Borel, T; de Azambuja, F; Johnson, D; Sorrentino, JP; Udokwu, C; Davis, I; Liu, A; Altman, RA Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway. J Med Chem 64:797-811 (2021) [PubMed]  Article 
Target
Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms:
ACMSD | ACMSD_HUMAN | Picolinate carboxylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38037.38
Organism:
Homo sapiens (Human)
Description:
Q8TDX5
Residue:
336
Sequence:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
  
Inhibitor
Name:
BDBM50565951
Synonyms:
CHEMBL4796997
Type:
Small organic molecule
Emp. Form.:
C18H15N3O3S2
Mol. Mass.:
385.46
SMILES:
OC(=O)Cc1cccc(CSC2NC(=O)C(C#N)=C(N2)c2cccs2)c1 |c:17|
Structure:
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