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Target
Protein-tyrosine-phosphatase
Ligand
BDBM50131100
Substrate
n/a
Meas. Tech.
ChEBML_210868
IC50
2900±n/a nM
Citation
 Lee, K; Gao, Y; Yao, ZJ; Phan, J; Wu, L; Liang, J; Waugh, DS; Zhang, ZY; Burke, TR Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase. Bioorg Med Chem Lett 13:2577-81 (2003) [PubMed]  Article 
Target
Name:
Protein-tyrosine-phosphatase
Synonyms:
Secreted effector protein | Secreted protein-tyrosine phosphatase
Type:
PROTEIN
Mol. Mass.:
50881.86
Organism:
Yersinia pestis
Description:
ChEMBL_810616
Residue:
468
Sequence:
MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANVVLTQEDTAKLLQSTVKHNLNNYDLRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSALHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVGDDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
  
Inhibitor
Name:
BDBM50131100
Synonyms:
2-{4-[(S)-2-[(S)-4-Benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-2-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethyl]-phenoxy}-2-fluoro-malonic acid | CHEMBL312922
Type:
Small organic molecule
Emp. Form.:
C45H47FN4O12
Mol. Mass.:
854.8727
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OC(F)(C(O)=O)C(O)=O)cc1)NC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc12)C(N)=O
Structure:
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