Reaction Details Report a problem with these data
Target
YEATS domain-containing protein 4
Ligand
BDBM50566877
Substrate
n/a
Meas. Tech.
ChEMBL_2101946 (CHEMBL4810342)
IC50
>54000±n/a nM
Citation
 Ma, XR; Xu, L; Xu, S; Klein, BJ; Wang, H; Das, S; Li, K; Yang, KS; Sohail, S; Chapman, A; Kutateladze, TG; Shi, X; Liu, WR; Wen, H Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain. J Med Chem 64:10997-11013 (2021) [PubMed]  Article 
Target
Name:
YEATS domain-containing protein 4
Synonyms:
GAS41 | Glioma-amplified sequence 41 | NuBI-1 | NuBI1 | NuMA-binding protein 1 | Synonyms=GAS41 | YEATS4 | YETS4_HUMAN
Type:
PROTEIN
Mol. Mass.:
26503.71
Organism:
Homo sapiens
Description:
ChEMBL_118406
Residue:
227
Sequence:
MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKDI
  
Inhibitor
Name:
BDBM50566877
Synonyms:
CHEMBL4863719
Type:
Small organic molecule
Emp. Form.:
C18H19N5O
Mol. Mass.:
321.3764
SMILES:
O=C(NCc1ccc(CN2CCC2)cc1)c1ccc2nncn2c1
Structure:
Search PDB for entries with ligand similarity: