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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50058286
Substrate
n/a
Meas. Tech.
ChEMBL_201336 (CHEMBL806185)
IC50
80.0±n/a nM
Citation
 Meltzer, PC; Blundell, P; Zona, T; Yang, L; Huang, H; Bonab, AA; Livni, E; Fischman, A; Madras, BK A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. J Med Chem 46:3483-96 (2003) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50058286
Synonyms:
(1R,12R) | (1R,12S) | CHEMBL119561 | Diastereiosomer of [N-[2-[(3'-N'-Propyl-3''beta-(4-fluorophenyl)tropane-2''beta-carboxylic acid methyl ester)(2-mercaptoethyl)amino]acetyl]-2-aminoethanethiolato]rhenium(V) oxide | O-1186 | O-861 | O-927 | O-928 | [N-[2-[(3'-N'-Propyl-3''beta-(4-fluorophenyl)tropane-2'' alpha-carboxylic acid methyl ester)(2-mercaptoethyl)amino]acetyl]-2-aminoethanethiolato]rhenium(V) oxide | [N-[2-[(3'-N'-Propyl-3''beta-(4-fluorophenyl)tropane-2''beta-carboxylic acid methyl ester)(2-mercaptoethyl)amino]acetyl]-2-aminoethanethiolato]rhenium(V) oxide
Type:
Small organic molecule
Emp. Form.:
C24H33FN3O4ReS2
Mol. Mass.:
696.872
SMILES:
COC(=O)C1C2CCC(CC1c1ccc(F)cc1)N2CCCN1CCS[Re]2(=O)SCCN2C(=O)C1 |TLB:19:18:4.10.9:6.7,THB:11:10:18:6.7,2:4:18:6.7|
Structure:
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