Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50567638
Substrate
n/a
Meas. Tech.
ChEMBL_2103553 (CHEMBL4812056)
Ki
6.2±n/a nM
Citation
 Sharonova, T; Paramonova, P; Kalinin, S; Bunev, A; Gasanov, R?; Nocentini, A; Sharoyko, V; Tennikova, TB; Dar'in, D; Supuran, CT; Krasavin, M Insertion of metal carbenes into the anilinic N-H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms. Eur J Med Chem 218:0 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50567638
Synonyms:
CHEMBL4851505
Type:
Small organic molecule
Emp. Form.:
C18H20N2O4S
Mol. Mass.:
360.427
SMILES:
CC(C)C(C(=O)Nc1ccc(cc1)S(N)(=O)=O)C(=O)c1ccccc1
Structure:
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