Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50132537
Substrate
n/a
Meas. Tech.
ChEBML_1121
Ki
467±n/a nM
Citation
 López-Rodríguez, ML; Benhamú, B; Morcillo, MJ; Tejada, I; Avila, D; Marco, I; Schiapparelli, L; Frechilla, D; Del Río, J Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands. Bioorg Med Chem Lett 13:3177-80 (2003) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50132537
Synonyms:
2-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-ylmethyl)-1H-benzoimidazole-4-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide | CHEMBL320346
Type:
Small organic molecule
Emp. Form.:
C27H32N6O3
Mol. Mass.:
488.5814
SMILES:
O=C(NC1CN2CCC1CC2)c1cccc2nc(CN3CCN(CC3)c3ccc4OCOc4c3)[nH]c12 |TLB:2:3:9.10:7.6,(2.94,4.77,;1.62,4,;.28,4.75,;-1.06,3.98,;-.97,2.56,;-2.25,3.39,;-1.72,5.24,;-2,6.4,;-2.3,4.79,;-3.86,4.36,;-3.87,2.95,;1.62,2.45,;.29,1.68,;.29,.13,;1.62,-.64,;2.96,.13,;4.43,-.35,;5.35,.91,;6.88,.91,;7.65,-.43,;7.85,-1.65,;6.95,-3.24,;8.13,-4.22,;7.95,-2.9,;8.84,-1.41,;8.89,-5.55,;8.1,-6.88,;8.86,-8.21,;10.4,-8.23,;11.43,-9.38,;12.83,-8.76,;12.69,-7.23,;11.17,-6.9,;10.43,-5.55,;4.43,2.16,;2.96,1.68,)|
Structure:
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