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Target
Bcl2-associated agonist of cell death
Ligand
BDBM50568333
Substrate
n/a
Meas. Tech.
ChEMBL_2105122 (CHEMBL4813625)
Ki
1300±n/a nM
Citation
 Niu, Q; Deng, H; Zhang, Z; Xu, Q; Luan, S; Huang, M; Liu, D; Zhao, L Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Bioorg Med Chem Lett 47:0 (2021) [PubMed]  Article 
Target
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:
PROTEIN
Mol. Mass.:
18393.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_478760
Residue:
168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
  
Inhibitor
Name:
BDBM50568333
Synonyms:
CHEMBL4859740
Type:
Small organic molecule
Emp. Form.:
C35H29NO3
Mol. Mass.:
511.6097
SMILES:
Cc1cccc(-c2cn(CCOc3cccc4ccccc34)c3cccc(-c4ccccc4C(O)=O)c23)c1C
Structure:
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