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Target
Integrin beta-3
Ligand
BDBM50004058
Substrate
n/a
Meas. Tech.
ChEMBL_2106375 (CHEMBL4815050)
IC50
130±n/a nM
Citation
 Zaman, KAU; Park, JH; DeVine, L; Hu, Z; Wu, X; Kim, HS; Cao, S Secondary Metabolites from the Leather Coral-Derived Fungal Strain  J Nat Prod 84:466-473 (2021) [PubMed]  Article 
Target
Name:
Integrin beta-3
Synonyms:
GPIIIa | ITB3_RAT | Integrin beta-3 | Itgb3 | Platelet membrane glycoprotein IIIa
Type:
PROTEIN
Mol. Mass.:
86916.53
Organism:
Rattus norvegicus
Description:
ChEMBL_118300
Residue:
787
Sequence:
MRTRRPGQLWATLLALGALAGVVVGESNICTTRGVNSCQQCLAVSPVCAWCSDESLPQNSPRCNLKKNLLKDKCSPESIEFPVSEAQILEALPLSSKGSGDSAQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDLSFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMFISPPQAIKNPCYTMKSTCLPMFGYKHVLTLTDQVTRFNDEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVLPNDGRCHIGPDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVSLYQNYSELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPQQKEQSFTIKPVGFKDSLTVQVTFDCDCDCQAFAQPLSPRCNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCNCGDCVCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCEKCPTCPDACSFKKDCVECKKFNRGKLHEENNCNRFCRDDIELVKELTDTGKNAVNCTYKNEDDCVVRFQYYEDSSGRAVLYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT
  
Inhibitor
Name:
BDBM50004058
Synonyms:
(2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid | N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine | N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyrosine | tirofiban
Type:
Small organic molecule
Emp. Form.:
C22H36N2O5S
Mol. Mass.:
440.597
SMILES:
CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(O)=O
Structure:
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