Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50133516
Substrate
n/a
Meas. Tech.
ChEBML_213204
Ki
14200±n/a nM
Citation
Rittle, KE; Barrow, JC; Cutrona, KJ; Glass, KL; Krueger, JA; Kuo, LC; Lewis, SD; Lucas, BJ; McMasters, DR; Morrissette, MM; Nantermet, PG; Newton, CL; Sanders, WM; Yan, Y; Vacca, JP; Selnick, HG Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position. Bioorg Med Chem Lett 13:3477-82 (2003) [PubMed] Article
More Info.:
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
Inhibitor
Name:
BDBM50133516
Synonyms:
3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(6-methoxy-naphthalene-2-sulfonylamino)-N-methyl-propionamide | CHEMBL334257
Type:
Small organic molecule
Emp. Form.:
C27H33N3O4S
Mol. Mass.:
495.634
SMILES:
COc1ccc2cc(ccc2c1)S(=O)(=O)NC(Cc1ccc(CN)cc1)C(=O)N(C)C1CCCC1