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Target
Activin receptor type-1
Ligand
BDBM4077
Substrate
n/a
Meas. Tech.
ChEMBL_2107053 (CHEMBL4815728)
IC50
4.0±n/a nM
Citation
 Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem 215:0 (2021) [PubMed]  Article 
Target
Name:
Activin receptor type-1
Synonyms:
2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I
Type:
n/a
Mol. Mass.:
57158.32
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM4077
Synonyms:
2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethyl-6-phenyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one | 2-[4-(2-Diethylaminoethoxy)phenylamino]-8-ethyl-6-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one | pyrido[2,3-d]pyrimidin-7-one deriv. 54
Type:
Small organic molecule
Emp. Form.:
C27H31N5O2
Mol. Mass.:
457.5673
SMILES:
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1
Structure:
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