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Target
Cycloartenol-C-24-methyltransferase
Ligand
BDBM50409741
Substrate
n/a
Meas. Tech.
ChEMBL_203192 (CHEMBL804437)
IC50
28±n/a nM
Citation
 Magaraci, F; Jimenez, CJ; Rodrigues, C; Rodrigues, JC; Braga, MV; Yardley, V; de Luca-Fradley, K; Croft, SL; de Souza, W; Ruiz-Perez, LM; Urbina, J; Gonzalez Pacanowska, D; Gilbert, IH Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. J Med Chem 46:4714-27 (2003) [PubMed]  Article 
Target
Name:
Cycloartenol-C-24-methyltransferase
Synonyms:
24-sterol C-methyltransferase | CPH | SMT1 | SMT1_ARATH
Type:
PROTEIN
Mol. Mass.:
38266.01
Organism:
Arabidopsis thaliana
Description:
ChEMBL_415082
Residue:
336
Sequence:
MDLASNLGGKIDKSDVLTAVEKYEQYHVFHGGNEEERKANYTDMVNKYYDLATSFYEYGWGESFHFAQRWKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLTTKCLEALKQAGFEVIWEKDLAKDSPVPWYLPLDKNHFSLSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE
  
Inhibitor
Name:
BDBM50409741
Synonyms:
CHEMBL2069130
Type:
Small organic molecule
Emp. Form.:
C26H45NO2
Mol. Mass.:
403.641
SMILES:
CC(O)([C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C1CCCCN1
Structure:
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