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Target
Cathepsin S
Ligand
BDBM50135532
Substrate
n/a
Meas. Tech.
ChEBML_48682
IC50
710±n/a nM
Citation
 Greenspan, PD; Clark, KL; Cowen, SD; McQuire, LW; Tommasi, RA; Farley, DL; Quadros, E; Coppa, DE; Du, Z; Fang, Z; Zhou, H; Doughty, J; Toscano, KT; Wigg, AM; Zhou, S N-arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B. Bioorg Med Chem Lett 13:4121-4 (2003) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50135532
Synonyms:
3-{2-cyano-2-[1-(3-methyloxycarbonylanilino)-2-(3-methylphenyl)-(1S)-ethylcarboxamido]ethoxymethyl}benzoic acid | CHEMBL336115
Type:
Small organic molecule
Emp. Form.:
C29H29N3O6
Mol. Mass.:
515.5571
SMILES:
COC(=O)c1cccc(N[C@@H](Cc2cccc(C)c2)C(=O)N[C@@H](COCc2cccc(c2)C(O)=O)C#N)c1
Structure:
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