Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50135533
Substrate
n/a
Meas. Tech.
ChEBML_48521
IC50
2400±n/a nM
Citation
 Greenspan, PD; Clark, KL; Cowen, SD; McQuire, LW; Tommasi, RA; Farley, DL; Quadros, E; Coppa, DE; Du, Z; Fang, Z; Zhou, H; Doughty, J; Toscano, KT; Wigg, AM; Zhou, S N-arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B. Bioorg Med Chem Lett 13:4121-4 (2003) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50135533
Synonyms:
(S)-N-[(R)-Cyano-(3-tetrazol-1-yl-benzyloxymethyl)-methyl]-2-(3-oxo-1,3-dihydro-isobenzofuran-5-ylamino)-3-m-tolyl-propionamide | CHEMBL335426
Type:
Small organic molecule
Emp. Form.:
C29H27N7O4
Mol. Mass.:
537.5692
SMILES:
Cc1cccc(C[C@H](Nc2ccc3COC(=O)c3c2)C(=O)N[C@@H](COCc2cccc(c2)-n2cnnn2)C#N)c1
Structure:
Search PDB for entries with ligand similarity: