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Target
Protein ADM2
Ligand
BDBM50570400
Substrate
n/a
Meas. Tech.
ChEMBL_2112107 (CHEMBL4820957)
IC50
79±n/a nM
Citation
 Zirimwabagabo, JO; Jailani, ABA; Avgoustou, P; Tozer, MJ; Gibson, KR; Glossop, PA; Mills, JEJ; Porter, RA; Blaney, P; Wang, N; Skerry, TM; Richards, GO; Harrity, JPA Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization. J Med Chem 64:3299-3319 (2021) [PubMed]  Article 
Target
Name:
Protein ADM2
Synonyms:
ADM2 | ADM2_HUMAN | AM2
Type:
PROTEIN
Mol. Mass.:
15883.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_556927
Residue:
148
Sequence:
MARIPTAALGCISLLCLQLPGSLSRSLGGDPRPVKPREPPARSPSSSLQPRHPAPRPVVWKLHRALQAQRGAGLAPVMGQPLRDGGRQHSGPRRHSGPRRTQAQLLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSYG
  
Inhibitor
Name:
BDBM50570400
Synonyms:
CHEMBL4876643
Type:
Small organic molecule
Emp. Form.:
C30H31N5O4
Mol. Mass.:
525.5982
SMILES:
CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1C(N)=O
Structure:
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