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Target
Calcitonin gene-related peptide 2
Ligand
BDBM50570409
Substrate
n/a
Meas. Tech.
ChEMBL_2112109 (CHEMBL4820959)
IC50
4.0±n/a nM
Citation
 Zirimwabagabo, JO; Jailani, ABA; Avgoustou, P; Tozer, MJ; Gibson, KR; Glossop, PA; Mills, JEJ; Porter, RA; Blaney, P; Wang, N; Skerry, TM; Richards, GO; Harrity, JPA Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization. J Med Chem 64:3299-3319 (2021) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide 2
Synonyms:
Beta-CGRP | Beta-type CGRP | CALC2 | CALCB | CALCB_HUMAN | CGRP-II | Calcitonin gene-related peptide II
Type:
PROTEIN
Mol. Mass.:
13714.13
Organism:
Homo sapiens
Description:
ChEMBL_116903
Residue:
127
Sequence:
MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA
  
Inhibitor
Name:
BDBM50570409
Synonyms:
CHEMBL4857810
Type:
Small organic molecule
Emp. Form.:
C31H35N5O3
Mol. Mass.:
525.6413
SMILES:
CNCc1ccccc1CN(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C
Structure:
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