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Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Ligand
BDBM50135686
Substrate
n/a
Meas. Tech.
ChEMBL_161787 (CHEMBL768161)
IC50
>100000±n/a nM
Citation
 Gulledge, BM; Aggen, JB; Eng, H; Sweimeh, K; Chamberlin, AR Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors. Bioorg Med Chem Lett 13:2907-11 (2003) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms:
PP2AA_BOVIN | PPP2CA | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Type:
PROTEIN
Mol. Mass.:
35586.74
Organism:
Bos taurus
Description:
ChEMBL_161787
Residue:
309
Sequence:
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
  
Inhibitor
Name:
BDBM50135686
Synonyms:
(R)-2-((4E,6E)-(2S,3S)-3-Acetylamino-7-biphenyl-4-yl-2,6-dimethyl-hepta-4,6-dienoylamino)-propionic acid | CHEMBL98309
Type:
Small organic molecule
Emp. Form.:
C26H30N2O4
Mol. Mass.:
434.5274
SMILES:
C[C@@H](NC(=O)[C@@H](C)[C@@H](NC(C)=O)\C=C\C(\C)=C\c1ccc(cc1)-c1ccccc1)C(O)=O
Structure:
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