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Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Ligand
BDBM50135692
Substrate
n/a
Meas. Tech.
ChEMBL_161787 (CHEMBL768161)
IC50
>100000±n/a nM
Citation
 Gulledge, BM; Aggen, JB; Eng, H; Sweimeh, K; Chamberlin, AR Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors. Bioorg Med Chem Lett 13:2907-11 (2003) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms:
PP2AA_BOVIN | PPP2CA | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Type:
PROTEIN
Mol. Mass.:
35586.74
Organism:
Bos taurus
Description:
ChEMBL_161787
Residue:
309
Sequence:
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
  
Inhibitor
Name:
BDBM50135692
Synonyms:
CHEMBL100880 | N-[(2E,4E)-(1S,6S,7S)-7-Methoxy-4,6-dimethyl-1-((S)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-8-phenyl-octa-2,4-dienyl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C26H38N2O3
Mol. Mass.:
426.5915
SMILES:
CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@H](NC(C)=O)[C@H](C)C(=O)N1CCCC1
Structure:
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