Reaction Details Report a problem with these data
Target
Apoptosis regulator BAX
Ligand
BDBM50570680
Substrate
n/a
Meas. Tech.
ChEMBL_2112707 (CHEMBL4821557)
Ki
43±n/a nM
Citation
 Liu, G; Kim, H; Wang, P; Fricke, DR; Chen, H; Wang, T; Shen, Q; Zhou, J Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer. Eur J Med Chem 219:0 (2021) [PubMed]  Article 
Target
Name:
Apoptosis regulator BAX
Synonyms:
Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Type:
PROTEIN
Mol. Mass.:
21181.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100916
Residue:
192
Sequence:
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
  
Inhibitor
Name:
BDBM50570680
Synonyms:
CHEMBL4868313
Type:
Small organic molecule
Emp. Form.:
C20H13NO3
Mol. Mass.:
315.3221
SMILES:
Oc1ccccc1\C=C1/c2ccccc2-c2ccc(cc12)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: