Reaction Details Report a problem with these data
Target
Interleukin-15
Ligand
BDBM50571056
Substrate
n/a
Meas. Tech.
ChEMBL_2113696 (CHEMBL4822546)
IC50
>30000±n/a nM
Citation
 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Rational modification, synthesis and biological evaluation of N-substituted phthalazinone derivatives designed to target interleukine-15 protein. Bioorg Med Chem 39:0 (2021) [PubMed]  Article 
Target
Name:
Interleukin-15
Synonyms:
IL-15 | IL15_MOUSE | Il15 | Interleukin-15
Type:
PROTEIN
Mol. Mass.:
18588.73
Organism:
Mus musculus
Description:
ChEMBL_120403
Residue:
162
Sequence:
MKILKPYMRNTSISCYLCFLLNSHFLTEAGIHVFILGCVSVGLPKTEANWIDVRYDLEKIESLIQSIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEYSNMTLNETVRNVLYLANSTLSSNKNVAESGCKECEELEEKTFTEFLQSFIRIVQMFINTS
  
Inhibitor
Name:
BDBM50571056
Synonyms:
CHEMBL4863838
Type:
Small organic molecule
Emp. Form.:
C35H48Cl2N6O3SSi
Mol. Mass.:
731.851
SMILES:
[#6]-n1c(-[#6]-c2nn(-[#6]-[#6]-[#6]-[#8][Si;v4]([#6])([#6])C([#6])([#6])[#6])c(=O)c3ccccc23)nnc1-[#16]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6](=O)-[#7]-c1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: