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Target
Folate receptor alpha
Ligand
BDBM50571075
Substrate
n/a
Meas. Tech.
ChEMBL_2113842 (CHEMBL4822692)
IC50
1.4±n/a nM
Citation
 Venkatesh, C; Doorneweerd, DD; Xia, W; Putt, KS; Low, PS Folate-targeted verrucarin A reduces the number of activated macrophages in a mouse model of acute peritonitis. Bioorg Med Chem Lett 42:0 (2021) [PubMed]  Article 
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
  
Inhibitor
Name:
BDBM50571075
Synonyms:
CHEMBL4852455
Type:
Small organic molecule
Emp. Form.:
C40H51N15O17S
Mol. Mass.:
1045.988
SMILES:
NC(=N)NCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)CC[C@H](NC(=O)c1ccc(NCc2cnc3nc(N)[nH]c(=O)c3n2)cc1)C(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(O)=O |r|
Structure:
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