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Target
Melatonin receptor type 1A
Ligand
BDBM50136411
Substrate
n/a
Meas. Tech.
ChEBML_105102
Ki
21±n/a nM
Citation
 Sun, LQ; Chen, J; Mattson, RJ; Epperson, JR; Deskus, JA; Li, WS; Takaki, K; Hodges, DB; Iben, L; Mahle, CD; Ortiz, A; Molstad, D; Ryan, E; Yeleswaram, K; Xu, C; Luo, G Heterocyclic aminopyrrolidine derivatives as melatoninergic agents. Bioorg Med Chem Lett 13:4381-4 (2003) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50136411
Synonyms:
1-Cyclopropyl-3-[(S)-1-(2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-yl]-urea | CHEMBL136894
Type:
Small organic molecule
Emp. Form.:
C16H21N3O2
Mol. Mass.:
287.3568
SMILES:
O=C(NC1CC1)N[C@H]1CCN(C1)c1cccc2OCCc12
Structure:
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