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Target
Lysine--tRNA ligase
Ligand
BDBM50571530
Substrate
n/a
Meas. Tech.
ChEMBL_2115022 (CHEMBL4823963)
Kd
5750±n/a nM
Citation
 Lee, S; Kwon, NH; Seo, B; Lee, JY; Cho, HY; Kim, K; Kim, HS; Jung, K; Jeon, YH; Kim, S; Suh, YG Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis. Eur J Med Chem 218:0 (2021) [PubMed]  Article 
Target
Name:
Lysine--tRNA ligase
Synonyms:
KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN
Type:
PROTEIN
Mol. Mass.:
68044.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960665
Residue:
597
Sequence:
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
  
Inhibitor
Name:
BDBM50571530
Synonyms:
CHEMBL4852870
Type:
Small organic molecule
Emp. Form.:
C23H21N3O3S
Mol. Mass.:
419.496
SMILES:
COc1ccc(CCN(Cc2ccc(cc2)C(O)=O)c2nc3cccnc3s2)cc1
Structure:
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