Reaction Details Report a problem with these data
Target
Matrix metalloproteinase-26
Ligand
BDBM50137283
Substrate
n/a
Meas. Tech.
ChEBML_104566
IC50
744±n/a nM
Citation
 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett 14:47-50 (2003) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-26
Synonyms:
Endometase | MMP-26 | MMP26 | MMP26_HUMAN | Matrilysin-2 | Matrix metalloproteinase 26 | Matrix metalloproteinase-26
Type:
PROTEIN
Mol. Mass.:
29707.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_806653
Residue:
261
Sequence:
MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKCSSDIP
  
Inhibitor
Name:
BDBM50137283
Synonyms:
6-(benzyloxy)-N-hydroxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide | 6-Benzyloxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide | CHEMBL358539
Type:
Small organic molecule
Emp. Form.:
C24H24N2O6S
Mol. Mass.:
468.522
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NO
Structure:
Search PDB for entries with ligand similarity: