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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50137291
Substrate
n/a
Meas. Tech.
ChEBML_52888
IC50
2900±n/a nM
Citation
 Leban, J; Saeb, W; Garcia, G; Baumgartner, R; Kramer, B Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement. Bioorg Med Chem Lett 14:55-8 (2003) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50137291
Synonyms:
2-(4'-Bromo-3-chloro-biphenyl-4-ylcarbamoyl)-cyclopent-1-enecarboxylic acid | CHEMBL154908
Type:
Small organic molecule
Emp. Form.:
C19H15BrClNO3
Mol. Mass.:
420.684
SMILES:
OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1Cl)-c1ccc(Br)cc1 |t:3|
Structure:
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