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Target
Tyrosine-protein kinase Mer
Ligand
BDBM50571948
Substrate
n/a
Meas. Tech.
ChEMBL_2116014 (CHEMBL4824955)
IC50
4110±n/a nM
Citation
 Inoue, S; Yamane, Y; Tsukamoto, S; Murai, N; Azuma, H; Nagao, S; Nishibata, K; Fukushima, S; Ichikawa, K; Nakagawa, T; Hata Sugi, N; Ito, D; Kato, Y; Goto, A; Kakiuchi, D; Ueno, T; Matsui, J; Matsushima, T Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine derivatives as novel selective Axl inhibitors. Bioorg Med Chem Lett 48:0 (2021) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
2.7.10.1 | MERTK_MOUSE | Mer | Mertk | Proto-oncogene c-Mer | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110136.51
Organism:
Mus musculus
Description:
ChEMBL_120433
Residue:
994
Sequence:
MVLAPLLLGLLLLPALWSGGTAEKWEETELDQLFSGPLPGRLPVNHRPFSAPHSSRDQLPPPQTGRSHPAHTAAPQVTSTASKLLPPVAFNHTIGHIVLSEHKNVKFNCSINIPNTYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSIASVQRSDNGSYFCKMKVNNREIVSDPIYVEVQGLPYFIKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEKPERSPSVLTVPGLTETAVFSCEAHNDKGLTVSKGVHINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADRLSNGSVMVFNTSASPHLYEIQQLQALANYSIAVSCRNEIGWSAVSPWILASTTEGAPSVAPLNITVFLNESNNILDIRWTKPPIKRQDGELVGYRISHVWESAGTYKELSEEVSQNGSWAQIPVQIHNATCTVRIAAITKGGIGPFSEPVNIIIPEHSKVDYAPSSTPAPGNTDSMFIILGCFCGFILIGLILCISLALRRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSEELQNKLEDVVIDRNLLVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLQLEKLSESLPDAQDKESIIYINTQLLESCEGIANGPSLTGLDMNIDPDSIIASCTPGAAVSVVTAEVHENNLREERYILNGGNEEWEDVSSTPFAAVTPEKDGVLPEDRLTKNGVSWSHHSTLPLGSPSPDELLFVDDSLEDSEVLM
  
Inhibitor
Name:
BDBM50571948
Synonyms:
CHEMBL4870992
Type:
Small organic molecule
Emp. Form.:
C34H35F2N7O4
Mol. Mass.:
643.683
SMILES:
CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(C4CC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1
Structure:
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