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Target
D(3) dopamine receptor
Ligand
BDBM50572019
Substrate
n/a
Meas. Tech.
ChEMBL_2116073 (CHEMBL4825014)
Ki
1.2±n/a nM
Citation
 Cai, J; Huang, M; Wang, Y; Chen, X; Ji, M Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents. Bioorg Med Chem Lett 48:0 (2021) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50572019
Synonyms:
CHEMBL4855879
Type:
Small organic molecule
Emp. Form.:
C26H34N2O7
Mol. Mass.:
486.5574
SMILES:
[H][C@@]12COc3ccc(OC)cc3[C@@]1([H])OCCN2CCCCNC(=O)c1cc(OC)c(OC)c(OC)c1 |r|
Structure:
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