Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50137464
Substrate
n/a
Meas. Tech.
ChEBML_143777
IC50
12000±n/a nM
Citation
Beaulieu, PL; Bös, M; Bousquet, Y; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; LaPlante, S; Poupart, MA; Lefebvre, S; McKercher, G; Pellerin, C; Austel, V; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. Bioorg Med Chem Lett 14:119-24 (2003) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50137464
Synonyms:
1-Cyclohexyl-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide | CHEMBL178076 | N-(3,4-dimethoxyphenethyl)-1-cyclohexyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C29H32N4O3
Mol. Mass.:
484.5894
SMILES:
COc1ccc(CCNC(=O)c2ccc3n(C4CCCCC4)c(nc3c2)-c2ccccn2)cc1OC