Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50137491
Substrate
n/a
Meas. Tech.
ChEBML_143777
IC50
50000±n/a nM
Citation
Beaulieu, PL; Bös, M; Bousquet, Y; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; LaPlante, S; Poupart, MA; Lefebvre, S; McKercher, G; Pellerin, C; Austel, V; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. Bioorg Med Chem Lett 14:119-24 (2003) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50137491
Synonyms:
1-(4-Methyl-cyclohexyl)-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid | CHEMBL177835
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2
Mol. Mass.:
335.3996
SMILES:
CC1CCC(CC1)n1c(nc2cc(ccc12)C(O)=O)-c1ccccn1 |(-.42,-8.43,;.36,-7.11,;1.9,-7.12,;2.68,-5.79,;1.9,-4.46,;.37,-4.45,;-.4,-5.77,;2.68,-3.13,;1.78,-1.9,;2.68,-.65,;4.14,-1.13,;5.47,-.35,;6.81,-1.12,;6.81,-2.67,;5.47,-3.44,;4.14,-2.67,;8.14,-.33,;9.48,-1.1,;8.12,1.2,;.24,-1.9,;-.53,-.56,;-2.07,-.56,;-2.84,-1.89,;-2.07,-3.23,;-.4,-3.13,)|