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Target
RNA-directed RNA polymerase
Ligand
BDBM50137494
Substrate
n/a
Meas. Tech.
ChEBML_143777
IC50
120000±n/a nM
Citation
 Beaulieu, PL; Bös, M; Bousquet, Y; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; LaPlante, S; Poupart, MA; Lefebvre, S; McKercher, G; Pellerin, C; Austel, V; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. Bioorg Med Chem Lett 14:119-24 (2003) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50137494
Synonyms:
1-Cyclohexyl-2-(2,4,6-trimethyl-phenyl)-1H-benzoimidazole-5-carboxylic acid | CHEMBL178067
Type:
Small organic molecule
Emp. Form.:
C23H26N2O2
Mol. Mass.:
362.4647
SMILES:
Cc1cc(C)c(-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(C)c1 |(1.01,-2.08,;2.55,-2.08,;3.34,-3.41,;4.86,-3.41,;4.86,-4.95,;5.63,-2.1,;7.17,-2.11,;8.08,-.87,;9.54,-1.34,;10.87,-.57,;12.21,-1.34,;12.21,-2.88,;10.87,-3.65,;9.54,-2.88,;8.08,-3.36,;7.54,-4.79,;6.02,-5.05,;5.48,-6.49,;6.46,-7.68,;7.98,-7.43,;8.52,-5.98,;13.56,-.56,;14.89,-1.33,;13.54,.98,;4.88,-.75,;5.65,.58,;3.34,-.75,)|
Structure:
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