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Target
RNA-directed RNA polymerase
Ligand
BDBM50137476
Substrate
n/a
Meas. Tech.
ChEMBL_143776 (CHEMBL750249)
IC50
14000±n/a nM
Citation
 Beaulieu, PL; Bös, M; Bousquet, Y; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; LaPlante, S; Poupart, MA; Lefebvre, S; McKercher, G; Pellerin, C; Austel, V; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. Bioorg Med Chem Lett 14:119-24 (2003) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50137476
Synonyms:
1-Cyclohexyl-2-{4-[(3-dimethylamino-propylcarbamoyl)-methoxy]-phenyl}-1H-benzoimidazole-5-carboxylic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide | 1-cyclohexyl-N-(3,4-dimethoxyphenethyl)-2-(4-(2-(3-(dimethylamino)propylamino)-2-oxoethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide | CHEMBL264034
Type:
Small organic molecule
Emp. Form.:
C37H47N5O5
Mol. Mass.:
641.7996
SMILES:
COc1ccc(CCNC(=O)c2ccc3n(C4CCCCC4)c(nc3c2)-c2ccc(OCC(=O)NCCCN(C)C)cc2)cc1OC
Structure:
Search PDB for entries with ligand similarity: