Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4
Ligand
BDBM50572061
Substrate
n/a
Meas. Tech.
ChEMBL_2116084 (CHEMBL4825025)
Kd
77±n/a nM
Citation
 Baggio, C; Kulinich, A; Dennys, CN; Rodrigo, R; Meyer, K; Ethell, I; Pellecchia, M NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands. J Med Chem 64:11229-11246 (2021) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4
Synonyms:
EPHA4 | EPHA4_HUMAN | Ephrin receptor | Ephrin type-A receptor 4 | HEK8 | SEK | TYRO1
Type:
PROTEIN
Mol. Mass.:
109859.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586961
Residue:
986
Sequence:
MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMRTQMQQMHGRMVPV
  
Inhibitor
Name:
BDBM50572061
Synonyms:
CHEMBL4853905
Type:
Small organic molecule
Emp. Form.:
C54H69N11O8
Mol. Mass.:
1000.1946
SMILES:
COc1ccccc1-c1ccc(C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccc(O)cc23)NC(=O)[C@H]2CCC[C@H](N)C2)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)NCC(=O)Nc2ccc(CN3CCOCC3)cc2)cc1 |r|
Structure:
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