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Target
Voltage-dependent calcium channel subunit alpha-2/delta-1
Ligand
BDBM50164279
Substrate
n/a
Meas. Tech.
ChEMBL_2116664 (CHEMBL4825605)
Ki
19±n/a nM
Citation
 Fernández, A; Díaz, JL; García, M; Rodríguez-Escrich, S; Lorente, A; Enrech, R; Dordal, A; Portillo-Salido, E; Porras, M; Fernández, B; Reinoso, RF; Vela, JM; Almansa, C Piperazinyl Bicyclic Derivatives as Selective Ligands of the ?2?-1 Subunit of Voltage-Gated Calcium Channels. ACS Med Chem Lett 12:1802-1809 (2021) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Synonyms:
CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2-1 | Voltage-dependent calcium channel subunit delta-1 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 1 | Voltage-gated calcium channel subunit alpha-2/delta-1
Type:
Enzyme
Mol. Mass.:
124544.88
Organism:
Homo sapiens (Human)
Description:
P54289
Residue:
1103
Sequence:
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL
  
Inhibitor
Name:
BDBM50164279
Synonyms:
(S)-3-(aminomethyl)-5-methylhexanoic acid | (S)-3-Aminomethyl-5-methyl-hexanoic acid | CHEMBL1059 | CI-1008 | Lyrica | PD-144723 | PREGABALIN
Type:
Small organic molecule
Emp. Form.:
C8H17NO2
Mol. Mass.:
159.2261
SMILES:
CC(C)C[C@H](CN)CC(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: