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Target
Nitric oxide synthase, brain
Ligand
BDBM50230993
Substrate
n/a
Meas. Tech.
ChEBML_143499
IC50
4300±n/a nM
Citation
 Ueda, S; Terauchi, H; Yano, A; Ido, M; Matsumoto, M; Kawasaki, M 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett 14:313-6 (2003) [PubMed]  Article 
Target
Name:
Nitric oxide synthase, brain
Synonyms:
Constitutive NOS | N-NOS | NC-NOS | NOS type I | NOS1_MOUSE | Neuronal NOS | Nitric-oxide synthase, brain | Nos1 | bNOS
Type:
PROTEIN
Mol. Mass.:
160483.95
Organism:
Mus musculus
Description:
ChEMBL_143499
Residue:
1429
Sequence:
MEEHTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGTPTKAVDLSRQPSASKDQPLAVDRVPGPSNGPQHAQGRGQGAGSVSQANGVAIDPTMKNTKANLQDSGEQDELLKEIEPVLSILTGGGKAVNRGGPAKAEMKDTGIQVDRDLDGKLHKAPPLGGENDRVFNDLWGKGNVPVVLNNPYSENEQSPASGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEQICMGSIMLPSHHIRKSEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVEFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
  
Inhibitor
Name:
BDBM50230993
Synonyms:
(2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid | (2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate | (R)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-amino-5-(2-methylguanidino)pentanoic acid | (S)-2-amino-5-(3-methylguanidino)pentanoic acid | 2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | CHEMBL256147 | L-NMMA | N omega-methyl-L-arginine | N(G)-mono-methyl-L-arginine | N(G)-monomethyl-L-arginine | N-Monomethyl-L-arginine | N-gamma-monomethyl-L-arginine | NG-Monomethyl-L-Arginine | NG-monomethyl-L-arginine acetate | Ngamma-monomethyl-L-arginine | Targinine
Type:
Small organic molecule
Emp. Form.:
C7H16N4O2
Mol. Mass.:
188.2275
SMILES:
CNC(N)=NCCC[C@H](N)C(O)=O |r,w:4.4|
Structure:
Search PDB for entries with ligand similarity: