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Target
C-C chemokine receptor type 2
Ligand
BDBM50138367
Substrate
n/a
Meas. Tech.
ChEBML_41891
IC50
1480±n/a nM
Citation
 Kettle, JG; Faull, AW; Barker, AJ; Davies, DH; Stone, MA N-Benzylindole-2-carboxylic acids: potent functional antagonists of the CCR2b chemokine receptor. Bioorg Med Chem Lett 14:405-8 (2003) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50138367
Synonyms:
5-Chloro-1-(2-chloro-benzyl)-1H-indole-2-carboxylic acid | CHEMBL339842
Type:
Small organic molecule
Emp. Form.:
C16H11Cl2NO2
Mol. Mass.:
320.17
SMILES:
OC(=O)c1cc2cc(Cl)ccc2n1Cc1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: