Reaction Details Report a problem with these data
Target
Estrogen receptor
Ligand
BDBM50090462
Substrate
n/a
Meas. Tech.
ChEMBL_2118286 (CHEMBL4827352)
IC50
5.3±n/a nM
Citation
 Liang, J; Zbieg, JR; Blake, RA; Chang, JH; Daly, S; DiPasquale, AG; Friedman, LS; Gelzleichter, T; Gill, M; Giltnane, JM; Goodacre, S; Guan, J; Hartman, SJ; Ingalla, ER; Kategaya, L; Kiefer, JR; Kleinheinz, T; Labadie, SS; Lai, T; Li, J; Liao, J; Liu, Z; Mody, V; McLean, N; Metcalfe, C; Nannini, MA; Oeh, J; O'Rourke, MG; Ortwine, DF; Ran, Y; Ray, NC; Roussel, F; Sambrone, A; Sampath, D; Schutt, LK; Vinogradova, M; Wai, J; Wang, T; Wertz, IE; White, JR; Yeap, SK; Young, A; Zhang, B; Zheng, X; Zhou, W; Zhong, Y; Wang, X GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer. J Med Chem 64:11841-11856 (2021) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50090462
Synonyms:
CHEMBL3581693 | US20240043442, Example GDC-0810
Type:
Small organic molecule
Emp. Form.:
C26H20ClFN2O2
Mol. Mass.:
446.901
SMILES:
CC\C(=C(\c1ccc(\C=C\C(O)=O)cc1)c1ccc2[nH]ncc2c1)c1ccc(F)cc1Cl
Structure:
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