Reaction Details Report a problem with these data
Target
Stromelysin-3
Ligand
BDBM50138686
Substrate
n/a
Meas. Tech.
ChEMBL_106453 (CHEMBL717837)
Ki
410±n/a nM
Citation
 Matziari, M; Beau, F; Cuniasse, P; Dive, V; Yiotakis, A Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J Med Chem 47:325-36 (2004) [PubMed]  Article 
Target
Name:
Stromelysin-3
Synonyms:
MMP11_MOUSE | Matrix metalloproteinase 11 | Mmp11
Type:
PROTEIN
Mol. Mass.:
55452.62
Organism:
Mus musculus
Description:
ChEMBL_106453
Residue:
492
Sequence:
MARAACLLRAISRVLLLPLPLLLLLLLLLPSPLMARARPPESHRHHPVKKGPRLLHAALPNTLTSVPASHWVPSPAGSSRPLRCGVPDLPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQMAPTSPAPTLSSQAGTDTNEIALLEPETPPDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGYAYFLRGHLYWKFDPVKVKVLEGFPRPVGPDFFDCAEPANTFR
  
Inhibitor
Name:
BDBM50138686
Synonyms:
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-3-(2-trifluoromethoxy-phenylsulfanyl)-propyl]-phosphinic acid | CHEMBL323885
Type:
Small organic molecule
Emp. Form.:
C38H38F3N4O7PS
Mol. Mass.:
782.765
SMILES:
NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CSc1ccccc1OC(F)(F)F)CP(O)(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: