Reaction Details Report a problem with these data
Target
5'-3' exonuclease PLD3
Ligand
BDBM50572961
Substrate
n/a
Meas. Tech.
ChEMBL_2118724 (CHEMBL4827790)
IC50
8900±n/a nM
Citation
 Shirey, RJ; Turner, LD; Lairson, LL; Janda, KD Modulators of immunoregulatory exonucleases PLD3 and PLD4 identified by high-throughput screen. Bioorg Med Chem Lett 49:0 (2021) [PubMed]  Article 
Target
Name:
5'-3' exonuclease PLD3
Synonyms:
3.1.16.1 | 5'-3' exonuclease PLD3 | Choline phosphatase 3 | HindIII K4L homolog | Hu-K4 | PLD 3 | PLD3 | PLD3_HUMAN | Phosphatidylcholine-hydrolyzing phospholipase D3 | Phospholipase D3
Type:
PROTEIN
Mol. Mass.:
54704.21
Organism:
Homo sapiens
Description:
ChEMBL_12540
Residue:
490
Sequence:
MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL
  
Inhibitor
Name:
BDBM50572961
Synonyms:
CHEMBL4870571
Type:
Small organic molecule
Emp. Form.:
C17H18N4O4S
Mol. Mass.:
374.414
SMILES:
Cc1ccc(Cn2c(SCC(O)=O)nc3n(C)c(=O)n(C)c(=O)c23)cc1
Structure:
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