Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1E
Ligand
BDBM50573237
Substrate
n/a
Meas. Tech.
ChEMBL_2119291 (CHEMBL4828357)
Ki
>10000±n/a nM
Citation
 Kwag, R; Lee, J; Kim, D; Lee, H; Yeom, M; Woo, J; Cho, Y; Kim, HJ; Kim, J; Keum, G; Jeon, B; Choo, H Discovery of G Protein-Biased Antagonists against 5-HT J Med Chem 64:13766-13779 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1E
Synonyms:
5-HT-1E | 5-HT1E | 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) | 5-hydroxytryptamine receptor 1E | 5-hydroxytryptamine receptor 1E (5-HT-1E) (S31) | 5-hydroxytryptamine receptor 1E (5-HT-1E) (Serotonin receptor 1E) (5-HT1E) (S31). | 5HT1E_HUMAN | HTR1E | S31 | Serotonin (5-HT) receptor | Serotonin 1e (5-HT1e) receptor | Serotonin Receptor 1E
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41697.80
Organism:
Homo sapiens (Human)
Description:
gi_112822
Residue:
365
Sequence:
MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
  
Inhibitor
Name:
BDBM50573237
Synonyms:
CHEMBL4866412
Type:
Small organic molecule
Emp. Form.:
C14H17FN4
Mol. Mass.:
260.31
SMILES:
Fc1cccc(c1)-c1n[nH]cc1N1CCCNCC1
Structure:
Search PDB for entries with ligand similarity: