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Target
Histone deacetylase 1
Ligand
BDBM50015184
Substrate
n/a
Meas. Tech.
ChEMBL_2119611 (CHEMBL4828677)
IC50
25380±n/a nM
Citation
 Sandrone, G; Cukier, CD; Zrubek, K; Marchini, M; Vergani, B; Caprini, G; Fossati, G; Steinkühler, C; Stevenazzi, A Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors. ACS Med Chem Lett 12:1810-1817 (2021) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50015184
Synonyms:
BENZHYDROXAMIC ACID | BENZOHYDROXAMATE | CHEMBL16300 | N-Hydroxy-benzamide | N-hydroxybenzamide | benzoyl hydroxamic acid
Type:
Small organic molecule
Emp. Form.:
C7H7NO2
Mol. Mass.:
137.136
SMILES:
ONC(=O)c1ccccc1
Structure:
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