Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50139764
Substrate
n/a
Meas. Tech.
ChEMBL_72504 (CHEMBL683938)
Kd
0.075±n/a nM
Citation
 Shi, ZD; Lee, K; Wei, CQ; Roberts, LR; Worthy, KM; Fisher, RJ; Burke, TR Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity. J Med Chem 47:788-91 (2004) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50139764
Synonyms:
5-Methylindolyl derivative | CHEMBL423988
Type:
Small organic molecule
Emp. Form.:
C38H45N5O9P
Mol. Mass.:
746.7674
SMILES:
Cc1ccc2n(C[C@H]3CNC(=O)[C@H](CC(N)=O)NC(=O)C4(CCCCC4)NC(=O)[C@@H](CC([O-])=O)[C@H](\C=C\C3)c3ccc(CP([O-])([O-])=O)cc3)ccc2c1 |t:36|
Structure:
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