Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-9
Ligand
BDBM50573691
Substrate
n/a
Meas. Tech.
ChEMBL_2120236 (CHEMBL4829383)
IC50
28±n/a nM
Citation
 Lee, MJ; Bhattarai, D; Jang, H; Baek, A; Yeo, IJ; Lee, S; Miller, Z; Lee, S; Hong, JT; Kim, DE; Lee, W; Kim, KB Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease. J Med Chem 64:10934-10950 (2021) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-9
Synonyms:
LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:
PROTEIN
Mol. Mass.:
23256.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
  
Inhibitor
Name:
BDBM50573691
Synonyms:
CHEMBL4845896
Type:
Small organic molecule
Emp. Form.:
C21H25N3O6
Mol. Mass.:
415.4397
SMILES:
C[C@@]1(CO1)C(O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)c1cccc(=O)[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity: