Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50574147
Substrate
n/a
Meas. Tech.
ChEMBL_2121944 (CHEMBL4831091)
Ki
8.7±n/a nM
Citation
 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action. Eur J Med Chem 225:0 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50574147
Synonyms:
CHEMBL4868581
Type:
Small organic molecule
Emp. Form.:
C13H15N3O3S2Se
Mol. Mass.:
404.37
SMILES:
[#7]S(=O)(=O)c1ccc([Se;v2][#6]-[#6](-[#8])-[#6]-[#16]-c2ncccn2)cc1
Structure:
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