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Target
Serine/threonine-protein kinase A-Raf
Ligand
BDBM50574708
Substrate
n/a
Meas. Tech.
ChEMBL_2123067 (CHEMBL4832300)
IC50
7058±n/a nM
Citation
 Zaraei, SO; Sbenati, RM; Alach, NN; Anbar, HS; El-Gamal, R; Tarazi, H; Shehata, MK; Abdel-Maksoud, MS; Oh, CH; El-Gamal, MI Discovery of first-in-class imidazothiazole-based potent and selective ErbB4 (HER4) kinase inhibitors. Eur J Med Chem 224:0 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase A-Raf
Synonyms:
ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase
Type:
Enzyme
Mol. Mass.:
67610.81
Organism:
Homo sapiens (Human)
Description:
P10398
Residue:
606
Sequence:
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
  
Inhibitor
Name:
BDBM50574708
Synonyms:
CHEMBL4866102
Type:
Small organic molecule
Emp. Form.:
C22H16N4OS
Mol. Mass.:
384.454
SMILES:
C(Oc1cccc(c1)-c1nc2sccn2c1-c1ccncn1)c1ccccc1
Structure:
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