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Target
Phenylalanine--tRNA ligase, mitochondrial
Ligand
BDBM50140716
Substrate
n/a
Meas. Tech.
ChEBML_154873
IC50
>100000±n/a nM
Citation
 Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. Bioorg Med Chem Lett 14:1339-42 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine--tRNA ligase, mitochondrial
Synonyms:
FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN
Type:
PROTEIN
Mol. Mass.:
52367.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154870
Residue:
451
Sequence:
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF
  
Inhibitor
Name:
BDBM50140716
Synonyms:
5'-(3-chloro-4-methylphenyl)-3'-phenyl-(3'R,3a'S,6a'R)-spiro[2,3-dihydro-1H-indene-2,1'-perhydropyrrolo[3,4-c]pyrrole]-1,3,4',6'-tetraone | CHEMBL26380 | CHEMBL26415
Type:
Small organic molecule
Emp. Form.:
C27H19ClN2O4
Mol. Mass.:
470.904
SMILES:
Cc1ccc(cc1Cl)-n1c(O)c2C(NC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Structure:
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